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日本研究人员关于肯尼迪病人吞咽问题研究的一篇论文

病友黑-阿米其找到一篇5月24日发表的论文,是日本的研究小组开展的肯尼迪病人吞咽问题研究的报告。现将论文摘要和译文发布如下,供病友们参考。

Swallowing markers in spinal and bulbar muscular atrophy

Abstract

Objective
We examined the characteristics of dysphagia in spinal and bulbar muscular atrophy, a hereditary neuromuscular disease causing weakness of limb, facial, and oropharyngeal muscles via a videofluoroscopic swallowing study, and investigated the plausibility of using these outcome measures for quantitative analysis.

Methods
A videofluoroscopic swallowing study was performed on 111 consecutive patients with genetically confirmed spinal and bulbar muscular atrophy and 53 age- and sex-matched healthy controls. Swallowing of 3-mL liquid barium was analyzed by the Logemann's Videofluorographic Examination of Swallowing worksheet.

Results

Of more than 40 radiographic findings, the most pertinent abnormal findings in patients with spinal and bulbar muscular atrophy, included vallecular residue after swallow (residue just behind the tongue base), nasal penetration, and insufficient tongue movement (P < 0>

Interpretation

Dysphagia of spinal and bulbar muscular atrophy was characterized by impaired tongue movement in the oral phase and nasal penetration followed by pharyngeal residues, which resulted in multiple swallowing sessions and laryngeal penetration。Although major limitations of reproducibility and radiation exposure still exist with videofluoroscopy, pharyngeal residue after initial swallowing and the penetration–aspiration scale might serve as potential outcome measures in clinical studies.

(译文)
  Swallowing markers in spinal and bulbar muscular atrophy
       脊髓延髓肌萎缩症的吞咽特征

目的:
 我们检验了脊髓延髓肌萎缩病吞咽困难的特征问题。这个病是遗传性神经肌肉疾病,由肢体,面部以及吞咽肌肉的萎缩力弱引起。我们通过视频荧光方法对吞咽问题进行了研究并且检测了使用这种测量方法定量分析的合理性。

方法:

 对111位基因测量确定的脊髓延髓肌萎缩病人以及53位年龄和性别相匹配的健康人进行了视频荧光吞咽问题研究。借助于罗格曼视频荧光检测技术,采用吞咽3毫升钡盐溶液后,进行吞咽工作表的分析。

结果:
 视频图片显示多于40位患有脊髓延髓肌萎缩症的病人和健康测试者比较,存在相关的异常表现,包括吞咽后存在的会厌残留(残留物恰恰存在于舌根后部),鼻渗透以及舌运动的不足。定量分析表明,这些病人的原初吞咽后的咽喉部残留和口腔残留,多次吞咽的进行以及渗透-吸入量比健康人都有着明显的恶化。对患有脊髓延髓萎缩病,没有主观吞咽困难的病人也进行了很多次的喉咙深部的观测。

解释:
 脊髓延髓肌萎缩的吞咽困难以口和鼻深部的舌运动障碍及接续的咽部残留所表征,这种残留是多次吞咽和喉咙深部的残留。尽管视频荧光分析存在着实验重复性和辐射暴露的主要局限性,但是初次吞咽后咽部残留及渗透吸收量表在临床研究上仍然可以作为一种有潜力的方法。




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